Document Type : Research Article
Authors
1
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O.Box 87317-51167, I. Iran
2
Department of Applied Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
3
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R.Iran
10.22091/jaem.2026.17167.1060
Abstract
LaCoO3 perovskite nanoparticles were synthesized through a citrate-based sol–gel auto-combustion route and investigated as reusable heterogeneous catalytic materials for ultrasound-assisted Biginelli condensation. Structural and physicochemical characterization using XRD, FT-IR, SEM–EDX, elemental mapping, and BET analysis confirmed the formation of nanocrystalline LaCoO3 with a crystallite size of approximately 9–10 nm. The catalyst efficiently promoted the synthesis of dihydropyrimidinone derivatives under mild conditions using an ethanol/water medium and ultrasonic irradiation. Optimization experiments identified 0.005 g catalyst, 208 W ultrasonic power, and 10 min irradiation as favorable conditions, providing high product yields. The catalyst could be readily recovered and reused over consecutive reaction cycles with only a modest decrease in catalytic activity. The combination of a stable perovskite catalytic material, mild reaction conditions, short processing time, and catalyst recyclability highlights the potential of LaCoO3-based materials for more sustainable catalytic processes. Overall, these findings underscore the potential of perovskite-based nanocatalysts as sustainable, cost-effective alternatives for green organic synthesis, with promising implications for broader pharmaceutical and industrial applications.
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