Colorimetric Sensor Based on the Interaction of Sildenafil Citrate and Silver Nanoparticles

Document Type : Research Article

Authors

1 Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

2 aDepartment of Chemistry, Faculty of Science, University of Qom, Qom, Iran

10.22091/jaem.2024.11043.1015

Abstract

This study introduces a simple, cost-effective, and highly sensitive colorimetric method for detecting and quantifying Sildenafil Citrate based on the aggregation of citrate-coated silver nanoparticles (AgNPs). The AgNPs were synthesized through the reduction of silver nitrate with sodium borohydride. Under optimized conditions, the presence of Sildenafil Citrate induces a distinct color change in the AgNP solution from light yellow to red, proportional to the Sildenafil Citrate concentration. This aggregation causes a decrease in the localized surface plasmon resonance (LSPR) absorbance at 394 nm and the emergence of a new peak at 530 nm. A linear correlation was established between the Sildenafil Citrate concentration and the absorbance ratio (A530/A394) in the range of 0.34–3.1 µM, with an impressive detection limit of 0.005 µM. The method was successfully applied to quantify Sildenafil Citrate in pharmaceutical tablets, demonstrating high accuracy, excellent stability, and practical applicability for quality control in health products.

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Advances in Energy and Materials Research
Volume 1, Issue 4
December 2024
Pages 4-11

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